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Original Article

ECB. 2014; 3(10): 1020-1026


SYNTHESIS OF NEW INTERCALATED QUINONES AND THEIR CYTOTOXIC EFFECTS ON CANCER CELL LINES

Feyriel Dridi, Nathalie Bar, Odile Sainte-Catherine, Messaoud Hachemi, Marc Lecouvey, Didier Villemin.




Abstract

Naphthoquinones with benzofuran or benzodioxan ring were obtained from dichloronaphthoquinone and were fully
characterized. The new benzodioxanes were tested on 4 cancer cells and one of them, a derivative from methyl pyrogallate
was found very cytotoxic for cancer cells.

Key words: naphthoquinone; benzofurane; benzodioxine; antitumor activity; cytotoxicity






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