Studies on subchronic toxicity of thiamethoxam and its amelioration by quercetin on oxidative stress and antioxidant parameters in male rats were conducted. Ninety six (96) adult male rats were divided in 6 groups for 60 and 90 days study, each comprising of 8 rats. Group I was kept as control and received 2% gum acacia. Groups II, III, IV, V, VI were administered with lower dose of TMX (2.5% MTD), higher dose of TMX (5.0% MTD), quercetin (50mg/kg), lower dose of TMX (2.5% MTD) + Qu (50mg/kg) and higher dose of TMX (5.0% MTD) + Qu (50mg/kg), respectively. Oxidative stress parameters such as lipid peroxidation (MDA) and protein carbonyl content (PCC) was seen to have increased and antioxidant parameters such as superoxide dismutase (SOD) and total thiols decreased significantly. Quercetin in this study exhibited amelioration effect by reversing the effect of thiamethoxam on these parameters investigated.
Key words: Subchronic exposure, thiamethoxam, quercetin, oxidative stress, antioxidant parameters.
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