According to the previous studies, it has been noted many times that oxidative balance is disrupted in bipolar disorder. However, we did not found any research investigating the relationship between Urotensin-II (U-II) levels and oxidative metabolism among bipolar disorder patients in the literature. In this study, we aimed to investigate the relationship between U-II levels and oxidative metabolism among bipolar disorder patients in the manic episode.
Forty-two patients diagnosed as bipolar disorder manic episode according to DSM-5 and 55 healthy controls enrolled in the study. Serum total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), U-II and oxidative stress index (OSI) measurements were done in the biochemistry laboratory of Gaziantep University. When TAS, TOS, OSI, NO, and U-II levels were compared between bipolar disorder manic episode patients and control group; TAS, TOS, OSI, NO and U-II levels were significantly higher in the patient group than the control group (p=0.003, p=0.001, p=0.001, p=0.001 and p=0.009 respectively). According to the correlation analysis, U-II levels were found to have a weak linear correlation in the positive direction with TOS and OSI (r=0.326, p=0.035 for TOS; and r=0.369, p=0.016 for OSI). In the earlier studies, data have been obtained about the effects of U-II on behavior, sleep, inflammatory system and oxidative metabolism and relevant hypotheses have been established. In the light of these studies in the literature, our study proposes that increased U-II levels could be a factor affecting the elevated oxidative stress and inflammation in patients with bipolar disorder manic episode. Our study is the first one to examine relationship between U-II levels and oxidative parameters in manic episode of bipolar disorder; therefore, it may significantly contribute to the literature.
Key words: Bipolar disorder, urotensins, nitric oxide, oxidative stress
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