Abstract

A simple and efficient synthesis of 4-allyl-5-(4-R1)-phenylthiomethyl-1,2,4-triazole-3-yl-mercaptoacetic acid derivatives 7a-l is described herein. This technique uses a direct alkylation 3-mercapto-4-allyl-5-(4-R1)-phenylthiomethyl-1,2,4-triazoles 5a-b, with substituted chloracetic acid anilides 6a-k, and 4'-bromo-2-chloroacetophenone 6l. The probability of anti-ulcer activity of the newly synthesized substances 5a-b and 7a-l was simulated by the computer program PASS and docking studies. The findings show that all substances of this group may be used for the treatment NSAID-inducеd ulcers.

Key words: synthesis, anti-ulcer activity, rational drug design, triazoles.