The protiated (H2O) and deuteriated (D2O) crystallohydrates of quinoline N-oxide, 2-methylquinoline N-oxide and 4-methylquinoline Noxide demonstrate different behavior at ambient conditions, namely, the deuteriated dihydrates undergo solid state transformation into crystalline anhydrous or hemihydrate forms, while protiated dihydrates loss 3D periodicity. In attempts to explain this phenomenon, the crystal structures of the six compounds – namely, quinoline N-oxide and quinoline N-oxide dihydrate, 2-methylquinoline N-oxide hemideuteriohydrate and 4-methylquinoline N-oxide dihydrate, 4-methylquinoline N-oxide and 4-methylquinoline N-oxide dihydrate – were analyzed.
Key words: quinoline N-oxide; 2-methylquinoline-N-oxide; 4-methylquinoline-N-oxide; crystallohydrates ; deuteriohydrates; dehydration,
crystal structure; powder X-ray diffraction
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