Abstract
Background: Studies have indicated that there is alteration of endogenous morphine after surgical interventions. As surgical interventions either clinical or experimental are carried out under anaesthesia. So, it cannot be concluded that the altered endogenous morphine is due to only surgical trauma. The research was, is there any anaesthetic effect on the endogenous morphine? Objective: objective of the current study was to determine any effect of propofol anaesthesia on the endogenous morphine. Methods: Young male rats were injected either propofol anesthesia or intralipic control and scarified at day 1 and day 3 to obtain blood and serum samples. Endogenous morphine was quantified in the samples by using a morphine specific enzyme-linked immunosorbent assay kit. Results: one way ANVOA showed a significant effect of treatment at day 1 between propofol and intralipidic control (P
Key words: Key words: endogenous morphine, propofol, anaesthesia, circadian rhythms, intralipid.
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