Parkinson's disease (PD) is characterized by rigidity, resting tremor, instability, and bradykinesia. Although not necessarily heritable, Parkinson may run in families in specific combinations of mutations in certain genes. In this review, we aim to summarize the list of genes that are involved in the inheritance of PD. The online databases such as PubMed, ScienceDirect, and UpToDate were used to carry out a literature search for publications without any date or language restrictions. We used a combination of relevant search terms and identified publications and systematically screened titles, abstracts, and full texts of the collected publications. The study found that SNCA and leucine-rich repeat kinase 2 (LRRK2) genes may cause dominant expressions, while PINK1, DJ11, and PARKIN cause a recessive expression. The GBA and MAPT genes were reported as genetic risk factors in most of the studies.
Key words: Parkinson, genetic, SNCA, LRRK2, PARKIN, GBA, PINK1.
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