Abstract

Introduction: Insomnia is a sleep disorder in about 20% - 56% of patients. Insomnia is an indicator that predicts a poor prognosis of functional recovery. There is growing evidence about the importance of sleep in neuroplasticity and learning in stroke recovery, but sleep management has not generally been considered in stroke management and rehabilitation protocols.
Aims: To determine the relationship between insomnia severity and serum BDNF levels and other factors, namely stroke location, stroke severity, gender, age and depression with motor clinical outcomes in ischemic stroke patients.
Methods: Cross-sectional study. Insomnia was evaluated by the Insomnia Severity Index (ISI) score, clinical motor output was evaluated by the Barthel Index (BI) score and the Short-Fugl Mayer Assessment (S-FMA) score. Depression was evaluated with the Beck Depression Inventory score. Serum BDNF levels were measured at 5 - 7 days of onset. Stroke severity was assessed by the NIHSS score and the location of the stroke lesion was assessed by a non-contrast head CT scan. Bivariate and multivariate analysis of each factor on motor clinical outcome and multiple linear regression of all factors associated with motor clinical outcome, to assess the magnitude of the influence of these factors on motor clinical outcome in stroke patients. The results were significant if the p-value

Key words: Insomnia, age, NIHSS, motor clinical outcome, ischemic stroke