Abstract

A series of Schiff’s bases of p-tolylsulphonyl hydrazide were synthesized by using Eaton's reagent under solvent-free condition, characterized by spectroscopic data and for evaluated α-amylase inhibitory activity in vitro. Four among the studied compounds exhibited varying degrees of α-amylase inhibitory activity with IC50 values in the range of 115.48 to 169.42 µg mL-1. The observed results were supported by the molecular docking study performed to understand the binding interaction of the title compounds with the active site of αamylase enzyme. Resultssuggest that Schiff's bases of p-tolylsulphonyl hydrazide derivatives can act as potential antidiabetic drugs

Key words: α-Amylase, Eaton's reagent, Schiff's bases, Solvent-free, Molecular docking