Solid dispersion is one of the techniques for improving the dissolution rate by increasing the solubility. Many scientists have been attracted towards this technique as a way of improving bioavailability of drugs mainly those belonging to Biopharmaceutic Classification System class II and IV. Aim of writing this review article is to give detail insight into the solid dispersion, their types based on the molecular arrangement, various methods of their preparation along with characterization. This article discusses various methods of preparation of solid dispersions that mainly depend upon the types of surface active carrier and selection of which plays an important role in the successful preparation of solid dispersion. The present review proves the importance of solid dispersion in the area of drug delivery and will definitely help research scientists struggling hard to increase the oral bioavailability of various poorly soluble drugs.
Key words: Bioavailability, Biopharmaceutic Classification System, Dissolution, Drug delivery, Polymeric carriers, Solid dispersion, Solubility.
|
