Abstract

Metabolic syndrome (MetS) and prostate cancer (PCa) are among the diseases with a concerning prevalence. The reported cases for both medical dilemmas have been steady with no sign of abating at the moment. More worrying is that researchers have started to discover that some of the components of MetS associatively worsen the prognosis of PCa. Even though the relationship is not fully known, its manifestation could cause extra burden to the currently implemented treatment approaches. The use of plant bioactive compounds as an alternative treatment has gained recognition, provided that its mechanisms of action, tolerability, efficacy, safety, and cost-effectiveness are well understood. Therefore, the current review intended to highlight the potential of bioactive compounds derived from plants to simultaneously target MetS, PCa, and MetS–PCa codisease. Additionally, emphasis on the potential of Andrographis paniculata (AP) as a candidate for the treatment of MetS–PCa is also highlighted.

Key words: prostate cancer, metabolic syndrome, Andrographis paniculata, adiposity, hyperglycemia