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Original Research

Study of antibiotic utilization pattern in tertiary care teaching hospital

Sweta Kumari, Kavita Dhar Bagati, Bala Krishnan S.


Background: Infectious diseases are a prominent cause of mortality in the developing country. Antibiotics have performed a key function in lowering the morbidity and mortality rate due to infectious ailments while an irrational use of antibiotics will increase bacterial drug resistance and adverse drug events, as well.

Aim and Objective: This study was performed to evaluate the uses of antibiotics with route of administration and the number of antibiotics used in per prescription.

Materials and Methods: A prospective cross-sectional study conducted in indoor patients with collaboration of Santosh Medical College, Ghaziabad Uttar Pradesh, and All India Institute of Medical Sciences, Bhopal, Madhya Pradesh. Statistical analysis: SPSS (ver.22. IBM Corp.) was used. The data were checked frequency distribution and represented as cross-tabs. Pearson’s Chi-square statistic was used to find association between antibiotic use and various variables. Two-tailed alpha of < 0.05 was considered as statistically significant.

Results: A total of 172 prescriptions, from medicine, paediatrics department was taken for study out of 172 patients 101 were males and 71 were females. We found that in medicine majority of patients prescriptions both departments, in medicine 134 (39.3%), the most common antibiotics beta-lactam (piperacillin/tazobactam) 48 (14.1%) and the 2nd common was cephalosporins (ceftriaxone) 44 (12.9%). In pediatrics, prescription 38 (11.1%) prescription in that most common antibiotics was cephalosporins (cefixime) 18 (5.3%), the 2nd common beta-lactam (amoxicillin/clavulanic acid) 16 (4.7%) was used. Out of 172 prescriptions, 130 (75.6%) received (intravenous) iv route and 42 (24.4%) received oral route.

Conclusions: By way of making antimicrobial stewardship elements of our everyday practice, we can enhance patient protection and care, reduce the unnecessary use of valuable resources, and decrease resistance.

Key words: Antibiotic Stewardship, Diagnosis, Resistance

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