The present study aims to investigate whether anti-inflammatory properties and hepato-pancreas protective effect mediate the antihyperglycemic effect of Murraya koenigii. Twenty five Spraque-Dawley rats were induced hyperglycemia by streptozotocin and nicotinamide (STZ-NA). The hyperglycemic rats were treated with an ethanolic extract of Murraya koenigii 200 mg/kg b.w and 400 mg/kg b.w. One group was treated with glibenclamide (1 mg/kg b.w). After the administration of Murraya koenigii extract and glibenclamide for four weeks, the rats were sacrificed. Blood and organ samples were collected under a fasting condition. The rats were evaluated the expression of pro-inflammatory cytokines (TNF-α, IL-1β) and histopathological changed in liver and pancreas. The beneficial effects of Murraya koenigii accompanied by the anti-inflammatory and hepatoprotective effect of Murraya koenigii and increased the number and size of islet Langerhans. The present study reveals that Murraya koenigii possesses anti-inflammatory, hepatoprotective, and promote the regeneration of damaged pancreatic islet. This effect is accompanied by a decrease in plasma glucose levels.
Key words: Anti-inflammatory, histomorphological, hyperglycemia, Murraya koenigii
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