Massoia (Cryptocarya massoia) is an Indonesian endemic plant containing essential oils with massoia lactone as a dominant compound component. This study aims to clarify the inhalation effect of massoia lactone on body weight and lipid profile on Sprague Dawley rats. Chemical components of two fractionated portions among four fractions from massoia oil were identified to be composed of 97% and 1.4% massoia lactone, thus named as massoia lactone rich and poor fractions, respectively. The two fractions and massoia oil were further used for in vivo tests on 4 treatment groups (one group was negative control). The results showed that the experimental animals that inhaled massoia lactone rich fraction had the lowest body weight (ANOVA p
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