It was found that 3-alkoxy-4,5-dihydroxyimidazolidin-2-ones are the only products of interaction of N-alkoxyureas with arylglyoxals which have strong electronegative substituent in the forth position of the aryl moiety. The possibility of obtaining such products as 3-alkoxy-1-aryl-5-(4-carboxyphenyl)-4,5-dihydroxyimidazolidin-2-ones, 3-alkoxy-1-alkyl-5-(4-carboxyphenyl)-4,5-dihydroxyimidazolidin-2-ones and 3-alkoxy-1-phenyl-4,5-dihydroxy-5-(4-nitrophenyl)-imidazolidin-2-ones has been verified in the experimental way. In most the cases 3-alkoxy-4,5-dihydroxyimidazolidin-2-ones were produced as a mixture of diastereomers.
Key words: N-alkoxy-N’-arylureas, N-alkoxy-N’-alkylureas, arylglyoxals; synthesis; 3-alkoxy-1-aryl-5-(4-carboxyphenyl)-4,5-dihydroxyimidazolidin-2-ones; 5-(4-carboxyphenyl)-4,5-dihydroxy-1-methyl-3-propyloxyimidazolidin-2-one; 3-alkoxy-4,5-dihydroxy-5-(4-
nitrophenyl)-1-phenylimidazolidin-2-ones.
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