Background: Fetomaternal alloimmune thrombocytopenia (FMAIT) is a rare disease that occurs when the mothers immune system produces antibodies against foreign platelet antigens, which are inherited from the father, in the foetus. These antibodies can cross the placental barrier and opsonized fetal platelets, causing fetal thrombocytopenia and increasing the risk of bleeding.
Case Presentation: In this study, the case of a 32-year-old female was presented with an affected first pregnancybwith FMAIT followed by surviving and healthy subsequent pregnancies. After the diagnosis of alloimmune thrombocytopenia was established in the first pregnancy, the management plan for the subsequent pregnancies was maternal administration of IVIG 1 g/kg/week, with the addition of hydrocortisone 0.5 mg/kg/ week from 20 weeks age of gestation until the fetal delivery.
Conclusion: FMAIT is one of the most common causes of antenatal fetal bleeding. Timely management is the best way to preserve pregnancy. Effective prophylaxis in antenatal care with IVIG infusion and corticosteroids has been reported. However, no mainstay mode of delivery has been agreed upon until now.
Key words: Autoimmune disease, Neonatal alloimmune thrombocytopenia, Fetal Intracranial haemorrhage, Anti-human platelet antigen, IVIG
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