ONE-POT SYNTHESIS OF PYRANO[2,3-c]PYRAZOLES USING LEMON PEEL POWDER AS A GREEN AND NATURAL CATALYST
Swati S. Ghodke, Sunil U. Tekale, Rashmi D. Pathrikar, Priya M. Khandare, László Kótai, Rajendra P. Pawar.
Abstract
A simple one-pot four-component synthesis of pyrano[2,3-c]pyrazoles has been achieved by the condensation of aldehydes, malononitrile, ethyl acetoacetate and hydrazine hydrate using lemon peel powder as a natural catalyst in ethanol under reflux condition. The advantages of this reaction are less reaction time, high yield, easy availability of the catalyst and green nature of the protocol.
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