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Research Article

ECB. 2020; 9(1): 22-27


SILVER ATOMS ENCAPSULATED IN G4 PAMAM (POLYAMIDOAMINE) DENDRIMERS AS A MODEL FOR THEIR USE IN NANOMEDICINE FOR PHOTOTHERAPY

Tamar G. Giorgadze, Irine G. Khutsishvili, Zaza G. Melikishvili, Vasil G. Bregadze.




Abstract

The main goals of the research are to study the drug delivery nanoparticle, G4 PAMAM (polyamidoamine) dendrimer, using spectroscopic and thermodynamic methods and, based on the unique properties of G4 PAMAM dendrimer, create new, stable nano-sized (∼5 nm) metalorganic nanocomplexes with silver atoms, which have a strong absorption in visible area and it can be used as a photo thermotherapeutic agent for the treatment of cancer cells.

Key words: G4 PAMAM (polyamidoamine) dendrimers, DNA, silver ions, nanomedicine; phototherapy.






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