Abstract

A series of functionally substituted pyrazole compounds have been synthesized using classical chemistry. Here we synthesized trifluoromethyl containing pyrazole compound by condensation of arylhydrazine derivative with ethyl (2E)-2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate. Pyrazole moieties have essential pharmaceutical and agrochemical activities. Our research-based on trifluoromethyl-containing pyrazole compounds synthesis also helps to improve biological activities due to fluorine binding affinity properties.

Key words: pyrazole; ethyl (2E)-2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate; arylhydrazine.