Industrial and environmental activities continuously release chemicals such as 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) that are hazardous to human health. This research seeks to assess the potentials of Allium cepa and Curcuma longa in suppressing 2,3,7,8-tetracholorodibenzo-p-dioxintoxicity. Forty (40) male Wistar rats weighing 121.77±16.23 g were divided into eight groups of five (5) rats per group. Positive control was fed standard diet, and given 2 µg/kg/week of TCDD in 0.5ml DMSO while normal control was fed standard diet and given 0.5ml dimethyl sulfoxide (DMSO)/kg body weight/week instead of TCDD. Other groups received 2µg/kg/week of TCDD in 0.5ml DMSO and were fed varied inclusion levels of powdered Allium cepa and Curcuma longa. On the 35th day of the experimental period, the rats were sacrificed and serum prepared from collected blood for antioxidant enzymes, malondialdehyde (MDA) and lipid profile determinations. All treated groups had significantly (p
Key words: ,3,7,8-tetracholorodibenzo-p-dioxin; glutathione peroxidase; glutathione reductase; malondialdehyde; Allium cepa; Curcuma longa.
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