The aim of this study was to assess the antiproliferative effect of extracts obtained from medicinal plants that grow wild in Jordan against human melanoma (WM136-1A) and colon cancer (Caco-2 cancer) cell lines. The selected plants are Ajuga chia (Lamiaceae), Micromeria myrtifolia (Lamiaceae), Micromeria nervosa (Lamiaceae), Origanum dayi (Lamiaceae), Salvia palaestina (Lamiaceae) Varthemia iphinoides (Asteraceae) and Bongardia chrysogonum (Berberidaceae). The results showed that M. nervosa and O. dayi exhibited antiproliferative activities against Caco-2 cancer cell line, with half maximal inhibitory concentrations (IC50) that equal 98±2.5 and 73.6±3.4 μg/ml respectively. Further, A. chia, B. chrysogonum and O. dayi exhibited antiproliferative activity against WM136-1A cancer cell line, with IC50 that equals 400±5.1, 98.1±3.2 and 245±3.6 μg/ml respectively. In conclusion, the extracts of M. nervosa, O. dayi, A. chia and B. chrysogonum showed promising antiproliferative potentials and can be good candidates for the development of novel anti-cancerous agents.
Key words: Ajuga chia, Micromeria myrtifolia, Micromeria nervosa, Origanum dayi, Salvia palaestina, Varthemia iphinoides, Bongardia chrysogonum, antiproliferatition
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