Bioenhancers are substances that can improve the bioavailability of drugs. Naringin is one of the naturally occurring fruit flavonoids found in citrus fruits that allows for increased absorption of various drugs. The main objective of the work was to determine the effect of naringin on the bioavailability of atorvastatin, the effective concentration, and the time at which the concentration of naringin was calculated. The bioavailability of atorvastatin was evaluated in rats with a single dose. The method was optimized using Design-Expert® software to modify the process, formulation, and concentration parameters. The study concluded that pre-treatment with 2 mg/kg of naringin for 15 minutes increased the bioavailability of atorvastatin by approximately ninefold. The atorvastatin layer is formed using 2.987 mg of crospovidone as a binder and the naringin layer is developed using 5 mg of polyvinylpyrrolidone as a disintegrant. After 1.53 minutes of administration, the Naringin layer disintegrates and atorvastatin disintegrates after 16.27 minutes of administration. By designing bilayer tablets of atorvastatin and naringin, the bioavailability of atorvastatin has improved significantly.
Key words: Bioavailability, Atorvastatin Calcium, Naringin, Drug Delivery Systems, Quality by Design, Enzyme inhibition
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