Indole and its various derivatives show diverse biological effects. In the present study, some novel indole derivatives like methyl-2-(1Hindole-3-yl) ethanoate derivatives (D1-D5) have been synthesized. Three Schiff bases (D6-D8) have been synthesized by the reaction of (D5) with substituted benzaldehydes. Co(II), Cu(II) and Ni(II) complexes of the Schiff bases have been prepared. All the compounds have been characterized by elemental analysis, molar conductivity, magnetic moment effect and spectroscopic techniques. The compounds exhibited moderate to significant anti-bacterial and anti-fungal activities against E. coli, S. aurous, B. subtitles, P. aeruginosin, A. niger, A. flavours, R. stolonifera and C. Albicans
Key words: Design, synthesis, biological evaluation triazole, indol.
|
