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Isolation of Epicatechin from the Stem Bark of Neocarya macrophylla (Sabine) Prance (Chrysobalanaceae)

A. J. Yusuf, M. I. Abdullahi, A. M. Musa, A. K. Haruna, V. Mzozoyana and A. Sanusi.




Abstract
Cited by 8 Articles

Purpose: Neocarya macrophylla has a wide range of medicinal uses in traditional medicine. The aim of the study was to isolate and characterize compound(s) from the stem bark of the plant.
Methods: (-)-Epicatechin (a flavan-3-ol) was isolated from the ethylaceate soluble fraction of the methanol stem bark extract of Neocarya macrophylla using a combination of silica gel and sephadex LH-20 column chromatography.
Results: The structure of the compound as (-)-epicatechin was confirmed on the basis of chemical test, 1D- & 2D-NMR spectroscopy and comparison with existing data in the literature.
Conclusion: This is the first report of isolation of epicatechin from the stem bark of the plant.

Key words: Neocarya macrophylla, stem bark, (-)-epicatechin, NMR analysis






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