Molecularly imprinted polymer (MIP) particles tailored for bisphenol A (BPA) were prepared using a 1:8:7 molar ratio of BPA the template, methacrylic acid (MAA) the functional monomer, and ethylene glycol dimethacrylate (EGDMA) the cross-linker. These colloidal particles were tested for rapid competitive binding by capillary electrophoresis with ultraviolet detection (CE-UV). Good interface binding efficiencies were obtained for BPA even in the presence of 2-hydroxy-4-methoxy benzophenone (HMB) as a structurally related compound at high concentrations. The specifically bound BPA could be desorbed rapidly out of the interface cavities by 5% triethylamine in methanol. However reusability was demonstrated by repeated injections of BPA that bound to MIP particles without regeneration of the cavities.
Key words: bisphenol A, capillary electrophoresis, competitive binding, molecularly imprinted polymers, reusability, specificity
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