Introduction: Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR) ratios are practical inflammation parameters. In Bipolar Disorder (BD) and Major Depressive Disorder (MDD), these parameters were reported higher than healthy controls (HC). We aim to compare NLR, PLR, MLR in HC, MDD, and BB.
Method: 46 patients with MDD and 43 patients with BD hospitalized between 2013-2017 and 40 HC were included in the study. White blood cell (WBC), neutrophil, lymphocyte, platelet, and monocyte numbers were noted retrospectively from complete blood counts at the time of admission, and NLR, PLR, and MLR were calculated from these.
Results: NLR and PLR were revealed higher in MDD than HC. NLR and neutrophil values were higher in BD than HC, and there was a positive correlation (r: 0.315) between NLR and patients with BD hospitalization period.
Conclusion: Findings of our study supported the inflammation hypothesis for major depressive disorder and bipolar disorder in adolescents. Larger scale studies are necessary to confirm these findings.
Key words: Keywords: Bipolar Disorder, Depression, White Blood Cells, inflammation
|
