THIONYL CHLORIDE CATALYZED SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME 2-BENZYLIDENE-1-TOSYLHYDRAZINES
V. Manikandan, S. Balaji, R. Senbagam, R. Vijayakumar, M. Rajarajan, G. Vanangamudi, R. Arulkumaran, R. Sundararajan, G. Thirunarayanan.
Abstract
More than 85 % yields of ten substituted 2-benzylidene-1-tosylhydrazines have been prepared by thionyl chloride assisted condensation of 1-tosylhydrazine and substituted benzaldehydes in room temperature. They are characterized by their physical constants, analytical, and spectroscopic data. The antimicrobial activities of these hydrazines were evaluated by Bauer-Kirby disc diffusion method.
Key words: 2-benzylidene-1-tosylhydrazines; IR and NMR spectra; antimicrobial activities.
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