Abstract

In India, cardiovascular disease (CVD) is one of the leading causes of death. All subjects are not accurately predicted for risk of CVD by traditional risk factors. To improve the present risk prediction model, a search of novel biomarkers is required to recognize the risk of cardiovascular events. Novel biomarkers involved in inflammation cascade and developing atherosclerosis and coronary heart disease are of utmost importance. The objectives were to study high sensitivity C-reactive protein (hs-CRP), lipoprotein A and LDL/HDL cholesterol ratio in acute coronary syndrome (ACS) and its association with ACS severity. Eighty patients (aged 18-70 years of either sex) with ACS (diagnosed based on clinical history, clinical examination, electrocardiogram changes, and creatine phosphokinase-MB) were studied at a tertiary care hospital from 2017 to 2020. High sensitivity C-reactive protein (hs-CRP), lipoprotein A, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were estimated and the association was obtained. Incidence of ACS was seen highest in 56-65 years (28.75%) with males contributing 85% patients. The most common diagnosis was ST-elevation myocardial infarction (78.75%). The hs-CRP levels and lipoprotein A were increased in 49 and 44 patients out of 80, respectively. Patients with high hs-CRP (n=43 of 48; p

Key words: Acute coronary syndrome, High sensitivity C-reactive protein, Lipoprotein A, Novel biomarkers