Diabetes mellitus (DM) is a major medical concern due to its high prevalence and potential deleterious effect on the patient physical and psychological state. Diabetes is a metabolic disorder resulting from a defect in insulin secretion, insulin action, or both. Insulin deficiency, in turn, leads to chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism. The liver is an insulin-guided organ as its behavior changes depending on the level of insulin in the blood. To stimulate diabetes, mice were injected intraperitoneally with a single dose of STZ (160 mg/kg B.W). In the present study, we investigated the effect of intravenous injection of mesenchymal stem cells obtained from 6-8 weeks adult CD-1 mice on the liver of streptozotocin-induced diabetic mice. Liver tissue glycogen content and the extent of liver degeneration were assessed using histological and ultra-structural studies.
Key words: Diabetes, STZ, stem cells, liver, histology, ultrastructure
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