Abstract

Objective: The aim of this study was to evaluate the dynamic thiol-disulphide homeostasis as a novel oxidative stress parameter in newly diagnosed and medication-naive general anxiety disorder (GAD) and panic disorder (PD) patients.
Methods: Medication-naive patients with GAD (n=21), PD (n=23) and healthy individuals (n=23) were enrolled. Patients were administered sociodemographic form, Beck Depression Inventory and Beck Anxiety Inventory. Routine biochemical parameters, native thiol, total thiol and disulphide parameters were measured in all patients and healthy individuals.
Results: The native thiol levels of the GAD and PD groups were found significantly lower than that of the control group (p

Key words: Thiol-disulphide homeostasis, generalized anxiety disorder, panic disorder