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Hematological Inflammatory Markers Are Associated with Parkinson’s Disease SeverityJoshua Adedayo Adegoke, Kanyinsola Elizabeth Onafowokan, Luqman Opeoluwa Ogunjimi, Anjolaoluwa Habibat Olawunmi, Evan Adetoye, Abidemi Rukayat Hamzat, Zulikhat Ajoke Maruwf, Ibironke Oluwafunmilayo Oyenuga, Toluwalope Ayankunle, Mutmainah Adebimpe Adesina, Olufunmbi Aduragbemi Akinola, Toluwani David Onadipe, Oluwatosin Adebayo Ogungbe, Ezekiel Olatunbosun Fabiyi, Bamidele Osalusi. Abstract |  Download PDF | Cited by 0 Articles |  Post | Objectives: Parkinson’s disease (PD) is a progressive neurodegenerative disorder with increasing prevalence in Sub-Saharan Africa. Hematological biomarkers, reflecting systemic inflammation, may predict disease severity. This study evaluates their prognostic potential in PD patients from Southwest Nigeria.
Methods: A hospital-based, cross-sectional study was conducted, involving 70 PD patients stratified into severe (stages 3–5, n=10) and non-severe (stages 1–2, n=60) groups using the Hoehn and Yahr (H & Y) scale, and 70 age- and sex-matched controls. Hematological parameters (white blood cell, red cell, platelet indices, and ratios) were analyzed using t-tests, binary logistic regression, and Receiver Operating Characteristic (ROC) curve analysis. A p-value < 0.05 was considered significant.
Results: Severe PD was observed in 14% of patients, with 76% being male. Compared to controls, PD patients had lower red blood cell counts (P=0.045), haemoglobin (P=0.014), and higher red cell distribution width-standard deviation (RDW-SD, P
Key words: Parkinson’s disease, hematological biomarkers, RDW-SD, PCT, inflammation, severity
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