Abstract

The aim of present study was to investigate the efficacy of Magnesium oxide and zinc oxide nanoparticles on healing of avulsion wounds in dogs. Nine adult animals weighing (M±SD: 15 ± 5) Kg were utilized in this study. Four circular wound (1.5 cm) including full skin thickness were induced in both sides on the dorsum of the dogs (tow on each side. The wounds were separated into 4 groups: group treated with normal saline (control group), MgO group treated locally with 150 μg of Nano magnesium oxide; ZnO group treated locally with 150 μg Nano zinc oxide; and Mixed group treated locally by combination of Nano-magnesium oxide (150 μg) and Nano-zinc oxide (150 μg). The second dose of Nanomaterials repeated locally in all treated groups after 3rd day from induced injury. Wounds diameter was clinically monitored (0-day, 7th, 14th, 17th, 18th, and 21th days) post-operation. Wound samples collected at 7,14,21 day postoperatively. Results: Clinically 21-day post injury, more wound contraction with a narrow diameter was observed in MgO, ZnO, and mixed groups when compared with control group Histopathological results revealed a good healing process in in MgO, ZnO, and mixed groups which characterized by normal structure of epidermis layer and subcutaneous layer and papillary layer. In conclusion of this study, Nano Zinc Oxide and Magnesium Oxide nanoparticles accelerate wound healing process

Key words: Nanoparticles, Magnesium Oxide, Zinc Oxide, Wound healing, Dogs.