Abstract

This study aimed to evaluate the neuroprotective effects of the systematically used ginger and the mechanism of action on alloxan invoked diabetic neuropathy with specific focus on management of painful diabetic neuropathy (PDN). Thirty adult male rats (200 to 250 g) were randomly divided into six groups; control, alloxan (100 mg/kg), ginger extract, phytosome ginger, phytosome ginger with glibenclamide, and ginger extract with glibenclamide. All treatments were administered orally for one month. Histopathological examination of the sciatic nerve showed that alloxan caused intensive neuropathic injury characterized by axonal degeneracy, breaks of myelin sheath, endoneurial thickening, vascular congestion, and inflammatory cell infiltration. Ginger extract partially reduced these changes, whereas phytosome ginger showed higher bioactivity in terms of enhanced nerve fiber organization and reduced Schwann cell and inflammatory.responses.

Key words: Alloxan, Diabetes, Ginger, Glibenclamide, Phytosome, Rats