Abstract

Background: Most of the parts of neem tree were studied in details by many researchers but neem root bark was not screened for antidiabetic effect. To evaluate antidiabetic effect of neem root bark this study was conducted.

Aims & Objective: The present study was undertaken to evaluate the 70% alcoholic neem root bark extract (NRE) in diabetes.

Materials and Methods: Basal blood sugar levels were estimated in overnight fasted wistar albino rats of either sex. To evaluate antihyperglycemic action of Neem root bark extract (NRE) OGTT was done by giving glucose orally 60 minutes after giving standard drug (Glibenclamide),Test drug (NRE) in the dose of 200,400 and 800 mg/kg and blood sugar levels were estimated every half hourly up to 4 hours. To evaluate hypoglycemic activity in alloxan induced diabetic rats similar doses once daily for 15 days. Blood sugar levels were estimated by using glucometer.

Results: For glucose tolerance test Glibenclamide significant (p< 0.01) reduction in blood sugar levels. The NRE showed statistically significant results in only 800 mg/kg dose. In comparison to glibenclamide it did not show. In alloxan induced diabetes Glibenclamide showed significant (p

Key words: Alloxan; Antihyperglycemic; Hypoglycemic; Neem Root Bark