Background: Pain is defined as an unpleasant sensation and emotional experience associated with or without tissue damage. Analgesics are the drugs that relieve pain. Statins are mainly employed in the treatment of hyperlipidaemias. Simvastatin belongs to HMG-CoA reductase inhibitors, which is the rate limiting step in the cholesterol synthesis. Analgesic effect of Simvastatin is a pleotropic effect, but the exact mechanism is not known. During our literature search we came across limited number of studies that evaluated the analgesic activity of simvastatin at different doses; however, the results were controversial at lower doses. Hence this study was under taken to evaluate analgesic activity Simvastatin at different doses in Wistar rats and also to compare its analgesic activity with Tramadol.
Aims and Objectives: (i) To evaluate analgesic activity Simvastatin at different doses in Wistar rats; (ii) To compare the analgesic activity of Simvastatin with Tramadol.
Materials and Methods: Analgesic activity of simvastatin was evaluated wistar rats using Tail Flick Model and Eddys Hot Plate Model. Normal saline with Polyethylene glycol (2 ml/kg), Tramadol (10 mg/kg), Simvastatin (5 mg/kg, 10 mg/kg and 30 mg/kg) dissolved in Polyethylene glycol, were given orally to the randomly divided 5 groups of 6 animals each. Maximum possible analgesia was calculated at 30, 60 and 90 min in both the models and compared between the 5 groups. Observations were analysed using ANOVA and post hoc Tukeys test.
Results: Simvastatin at doses 5 mg/kg and 10 mg/kg body weight produced significant Maximal possible analgesia at 30 and 60 min in both the models (
Key words: Analgesic Activity; Simvastatin; Tramadol; Tail Flick Model; Eddys Hot Plate
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