Abstract

Pemphigus vulgaris is a rare potentially life threatening auto immune disease it may cause severe blistering of the skin and mucous membranes lining the mouth, nose, throat, eye and genital area, blisters develop in the upper layer of the skin surface breaks away easily leaving raw areas erosions that can be extensive and painful. Our immune system wakes antibodies to fight infection Pemphigus vulgaris work against tissue in the body auto antibodies in Pemphigus vulgaris attack proteins called. Desmoglein this proteins present on the cells in the outer layer of the skin (epidermis) this causes skin lesions starts as thin walled fragile blisters a collection of clear fluid within the skin that burst easily leaving raw area known as erosions. This case report described the case of a patient who complained of hypotension and diabetes mellitus since one year the unknown organism/insect bite to the right leg after next day it produces swelling too much inflamed and the scaly appearance who was diagnosed as having Pemphigus vulgaris. Standard treatment for Pemphigus vulgaris is an oral corticosteroid, often with the addition with the adjuvant therapy to improve the disease control.

Key words: Pemphigus vulgaris, Desmoglein, Fragile blisters, Erosions