Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Review Article

SRP. 2012; 3(1): 31-36


Advanced Malarial Vaccines: A Promising Approach in the Treatment of Malaria

Manasa Veena Valupadasu, Uday Venkat Mateti.

Abstract
Malaria is a vector-borne parasitic infectious disease. The research is carried out on RTS, S/ASO1,
NYVAC-Plasmodium falciparum 7, SPF66 and the results suggested that these are very efficient
in treating malaria. RTS, S/ASO1 vaccine is composed of a hepatitis B surface antigen fused to
a recombinant antigen from part of the malaria Circumsporozoite protein in the AS01 adjuvant
used to target infected hepatocytes. Malaria vaccines are of three types: 1. Pre -erythrocytic
vaccines RTS, S/AS01 (commercial name: Mosquirix): the Circumsporozoite (CS) protein is the
most dominant surface antigen of this phase. 2. Blood stage vaccines. 3. Transmission blocking
vaccines. According to best dentists’ reviews, which will prevent any problems with teeth, it is
also to help prevent gum disease at the very least. The NYVAC-Pf7 by the intramuscular route
was safe and nontoxic and it is highly attenuated vaccinia virus with 7 P. falciparum genes inserted
into its genome, was tested in a phase I/IIa safety, immunogenicity, and efficacy vaccine. The
vaccine was safe and well tolerated but variably immunogenic. The results demonstrate that
NYVAC-P. farum 7 is an appropriate candidate vaccine for further evaluation in human clinical
trials. Vaccines are often the most cost-effective delivery system.Completely effective vaccine is
not yet available for malaria, although several vaccines are under development.

Key words: Malaria, NYVAC-Pf7, SPf66, Vaccines



Similar Articles

Ongoing Clinical Trials of Vaccines to Fight against COVID-19 Pandemic.
Chakraborty C, Sharma AR, Bhattacharya M, Sharma G, Saha RP, Lee SS
Immune network. 2021; 21(1): e5

Eugenol disrupts Plasmodium falciparum intracellular development during the erythrocytic cycle and protects against cerebral malaria.
Pontes KAO, Silva LS, Santos EC, Pinheiro AS, Teixeira DE, Peruchetti DB, Silva-Aguiar RP, Wendt CHC, Miranda KR, Coelho-de-Souza AN, Leal-Cardoso JH, Caruso-Neves C, Pinheiro AAS
Biochimica et biophysica acta. General subjects. 2021; 1865(3): 129813

Diagnostic performance of rapid diagnostic test, light microscopy and polymerase chain reaction during mass survey conducted in low and high malaria-endemic areas from two North-Eastern states of India.
Shankar H, Singh MP, Phookan S, Singh K, Mishra N
Parasitology research. 2021; ():

Bioactivity-directed evaluation of fruit of Kigelia africana (Lam.) benth. Used in treatment of malaria in Iwo, Nigeria.
Imran IZ, Elusiyan CA, Agbedahunsi JM, Omisore NO
Journal of ethnopharmacology. 2021; 268(): 113680

Variation in chemical composition and antimalarial activities of two samples of Terminalia albida collected from separate sites in Guinea.
Camara A, Haddad M, Traore MS, Chapeland-Leclerc F, Ruprich-Robert G, Fourasté I, Balde MA, Royo J, Parny M, Batigne P, Salon M, Coste A, Balde AM, Aubouy A
BMC complementary medicine and therapies. 2021; 21(1): 64

Variation in chemical composition and antimalarial activities of two samples of Terminalia albida collected from separate sites in Guinea.
Camara A, Haddad M, Traore MS, Chapeland-Leclerc F, Ruprich-Robert G, Fourasté I, Balde MA, Royo J, Parny M, Batigne P, Salon M, Coste A, Balde AM, Aubouy A
BMC complementary medicine and therapies. 2021; 21(1): 64

High-Dose Inactivated Influenza Vaccine Quadrivalent for Older Adults.
Chahine EB
The Annals of pharmacotherapy. 2021; 55(1): 89-97

Alphavirus-Based Antigen Preparation.
Lundstrom K
Methods in molecular biology (Clifton, N.J.). 2021; 2183(): 63-81


Full-text options






Advertisement
American Journal of Diagnostic Imaging

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.