Context: Drugs that are easily absorbed from the gastrointestinal tract (GIT) and have a short halflife
are eliminated quickly from the blood circulation, require frequent dosing. To avoid this, the
oral controlled release (CR) formulations have been developed in an attempt to release the drug
slowly into the GIT and maintain a constant drug concentration in the serum for longer period
of time. Such oral drug delivery devices have a restriction due to a short gastric retention time
(GRT), a physiological limitation. Therefore, devices which prolong gastric retention by retaining
the CR system in the stomach for a longer time have been developed and explored over the past
couple of years. Objectives: A mucoadhesive microsphere is one potential strategy for prolonging
GRT. The present review will give a comprehensive study of research done on the formulation of
microspheres using mucoadhesive polymers, the in vitro evaluation techniques employed with
a special discussion on recent in vivo techniques used. Results and Conclusion: Mucoadhesive
microspheres interact with mucous of GIT and are considered to be localized or trapped at the
adhesive site by retaining a dosage form at the site of action, or systemic delivery by retaining a
formulation in intimate contact with the absorption site which may result in prolonged gastric
residence time as well as improvement in intimacy of contact with underlying absorptive membrane
to achieve better therapeutic performance of drugs.
Gamma-Secretase Inhibitor (DAPT), a potential therapeutic target drug, caused neurotoxicity in planarian regeneration by inhibiting Notch signaling pathway.
Dong Z, Huo J, Liang A, Chen J, Chen G, Liu D
The Science of the total environment. 2021; 781(): 146735
Systematic Review of Phenolic Compounds in Apple Fruits: Compositions, Distribution, Absorption, Metabolism, and Processing Stability.
Feng S, Yi J, Li X, Wu X, Zhao Y, Ma Y, Bi J
Journal of agricultural and food chemistry. 2021; 69(1): 7-27
Yolk-shell structured Co@SiO@Void@C nanocomposite with tunable cavity prepared by etching of SiO as high-efficiency microwave absorber.
Wang B, Wu Q, Fu Y, Liu T
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Adele NC, Ngwenya BT, Heal KV, Mosselmans JFW
Environmental pollution (Barking, Essex : 1987). 2021; 279(): 116909
Natural Occurrence of Maize Gibberella Ear Rot and Contamination of Grain with Mycotoxins in Association with Weather Variables.
Dalla Lana F, Madden LV, Paul PA
Plant disease. 2021; 105(1): 114-126
Investigation of the Factors Responsible for the Poor Oral Bioavailability of Acacetin in Rats: Physicochemical and Biopharmaceutical Aspects.
Han DG, Cha E, Joo J, Hwang JS, Kim S, Park T, Jeong YS, Maeng HJ, Kim SB, Yoon IS
Pharmaceutics. 2021; 13(2):
Deep learning for in vivo near-infrared imaging.
Ma Z, Wang F, Wang W, Zhong Y, Dai H
Proceedings of the National Academy of Sciences of the United States of America. 2021; 118(1):
Metamaterial inspired wireless coil for clinical breast imaging.
Puchnin V, Solomakha G, Nikulin A, Magill AW, Andreychenko A, Shchelokova A
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