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Review Article

SRP. 2012; 3(1): 4-14

Mucoadhesive Microspheres as a Controlled Drug Delivery System for Gastroretention

Shadab Md, Gourav K. Singh, Alka Ahuja, Roop K. Khar, Sanjula Baboota, Jasjeet K. Sahni, Javed Ali.

Context: Drugs that are easily absorbed from the gastrointestinal tract (GIT) and have a short halflife
are eliminated quickly from the blood circulation, require frequent dosing. To avoid this, the
oral controlled release (CR) formulations have been developed in an attempt to release the drug
slowly into the GIT and maintain a constant drug concentration in the serum for longer period
of time. Such oral drug delivery devices have a restriction due to a short gastric retention time
(GRT), a physiological limitation. Therefore, devices which prolong gastric retention by retaining
the CR system in the stomach for a longer time have been developed and explored over the past
couple of years. Objectives: A mucoadhesive microsphere is one potential strategy for prolonging
GRT. The present review will give a comprehensive study of research done on the formulation of
microspheres using mucoadhesive polymers, the in vitro evaluation techniques employed with
a special discussion on recent in vivo techniques used. Results and Conclusion: Mucoadhesive
microspheres interact with mucous of GIT and are considered to be localized or trapped at the
adhesive site by retaining a dosage form at the site of action, or systemic delivery by retaining a
formulation in intimate contact with the absorption site which may result in prolonged gastric
residence time as well as improvement in intimacy of contact with underlying absorptive membrane
to achieve better therapeutic performance of drugs.

Key words: Absorption window, gamma scintigraphy, gastroretention, microspheres, mucoadhesion

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