Cancer pain is multidimensional and complex mechanism rarely presenting as a pure neuropathic,
visceral, or somatic pain syndrome. Rather, it may involve inflammatory, neuropathic, ischemic,
breakthrough pain mechanisms at multiple sites. Despite recommendation and demonstration
of patientsí need, these needs are not being met. Since two decades, a trend has been set
to exclude pain specialist from mainstream cancer pain management, they are being called
during the end stage making them the Ďlast resortí. Thus patients are missing out on benefits of
multidisciplinary care combining palliative care and pain medicine. Morphine licensing is still a
very painful procedure for the institutions trying to provide pain relief to the cancer patients and
due to this troublesome procedure of morphine licensing many patients do not get adequate
analgesia and die in pain. This review article highlights the importance of recognizing cancerrelated
pain and the need to optimize management. It emphasizes on pain management for the
cancer population with evidence-based multimodal and mechanism-based treatments and finally
to strengthen the relationship between palliative care, oncology, and pain medicine.
Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice: involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms.
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