The recent recognition of bisphosphonate use came into use for pathological conditions which includes osteonecrosis of the jaw (ONJ) and other bone diseases. This article highlights about bisphosphonate and its effect and affect on ONJ. Jaw necrosis is a complication associated with conditions such as radiotherapy, severe fungal or bacterial infections, and sarcoidosis or after intravenous bisphosphonate therapy. The intravenous bisphosphonates - pamidronate (Aredia) and zoledronic acid (Zometa), are often used to treat cancer-related hypercalcemia, Paget’s disease, symptoms from solid tumor bone metastasis and osteolytic lesions of multiple myeloma. Bisphosphonate related ONJ has been reported since 2003, in patients taking the drug, more often after dental procedures like extractions, minor surgeries, etc.
Bisphosphonates, Clinical practice, Mechanism, Osteonecrosis of jaw.
Individual versus collective debriefing after interprofessional training course simulation: the randomised DEBRIEF-SIM trial.
Ciceron F, Besch G, Benkhadra M, Rouge JA, Dupont G, Avena C, Laithier C, Girard C, Samain E, Pili-Floury S
Anaesthesia, critical care & pain medicine. 2021; (): 100828
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Leboucher J, Salami F, Ă–ztĂĽrk O, Heitzmann DWW, GĂ¶tze M, Dreher T, Wolf SI
Gait & posture. 2021; 84(): 127-136
Percutaneous tibial nerve stimulation in patients with severe low anterior resection syndrome: randomized clinical trial.
Marinello FG, JimĂ©nez LM, Talavera E, Fraccalvieri D, Alberti P, Ostiz F, Frago R, Blanco A, Pellino G, EspĂn-Basany E
The British journal of surgery. 2021; ():
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Baqi S, Naz A, Sayeed MA, Khan S, Ismail H, Kumar V, Somjimal H, Aneela J, Imtiaz S, Aftab S
Cureus. 2021; 13(2): e13107
Interests and needs of eye care providers in clinical decision support for glaucoma.
Stagg B, Stein JD, Medeiros FA, Cummins M, Kawamoto K, Hess R
BMJ open ophthalmology. 2021; 6(1): e000639
Medicine in motion: Opportunities, challenges and data analytics-based solutions for traditional medicine integration into western medical practice.
Jansen C, Baker JD, Kodaira E, Ang L, Bacani AJ, Aldan JT, Shimoda LMN, Salameh M, Small-Howard AL, Stokes AJ, Turner H, Adra CN
Journal of ethnopharmacology. 2021; 267(): 113477
Mechanism of Action of TiO: Recommendations to Reduce Uncertainties Related to Carcinogenic Potential.
Braakhuis HM, Gosens I, Heringa MB, Oomen AG, Vandebriel RJ, Groenewold M, Cassee FR
Annual review of pharmacology and toxicology. 2021; 61(): 203-223
Fever range whole body hyperthermia for re-irradiation of head and neck squamous cell carcinomas: Final results of a prospective study.
Zschaeck S, WeingĂ¤rtner J, Ghadjar P, Wust P, Mehrhof F, Kalinauskaite G, Ehrhardt VH, Hartmann V, Tinhofer I, Heiland M, Coordes A, Kofla G, Budach V, Stromberger C, Beck M
Oral oncology. 2021; 116(): 105240