Abstract
The recent recognition of bisphosphonate use came into use for pathological conditions which includes osteonecrosis of the jaw (ONJ) and other bone diseases. This article highlights about bisphosphonate and its effect and affect on ONJ. Jaw necrosis is a complication associated with conditions such as radiotherapy, severe fungal or bacterial infections, and sarcoidosis or after intravenous bisphosphonate therapy. The intravenous bisphosphonates - pamidronate (Aredia) and zoledronic acid (Zometa), are often used to treat cancer-related hypercalcemia, Paget’s disease, symptoms from solid tumor bone metastasis and osteolytic lesions of multiple myeloma. Bisphosphonate related ONJ has been reported since 2003, in patients taking the drug, more often after dental procedures like extractions, minor surgeries, etc.

Key words: Bisphosphonates, Clinical practice, Mechanism, Osteonecrosis of jaw.

Similar Articles

Central nervous system stimulation therapies in phantom limb pain: a systematic review of clinical trials.
Garcia-Pallero M�, Cardona D, Rueda-Ruzafa L, Rodriguez-Arrastia M, Roman P
Neural regeneration research. 2022; 17(1): 59-64

Association of knowledge and attitudes with practices of misuse of tranquilizers: A cohort study in Spain.
Mallah N, Figueiras A, Heidarian Miri H, Takkouche B
Drug and alcohol dependence. 2021; 225(): 108793

Individual versus collective debriefing after interprofessional training course simulation: the randomised DEBRIEF-SIM trial.
Ciceron F, Besch G, Benkhadra M, Rouge JA, Dupont G, Avena C, Laithier C, Girard C, Samain E, Pili-Floury S
Anaesthesia, critical care & pain medicine. 2021; (): 100828

Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data.
Nazmuddin M, Philippens IHCHM, van Laar T
Scientific reports. 2021; 11(1): 11751

Electromechanical coupling mechanism for activation and inactivation of an HCN channel.
Dai G, Aman TK, DiMaio F, Zagotta WN
Nature communications. 2021; 12(1): 2802