Diabetic Neuropathy is a most common Microvascular diabetic complication, associated with neuropathic disorder
causing nerve injury it mainly depends upon duration of hyperglycemia, elevation in glycosylated haemoglobin. Good
Neuropathic pain perception can improve Neuropathy. Single intraperitoneal injection of STZ (60 mgkg) was
administered to the albino wistar rats induced Diabetes, it showed marked hyperglycemia. Hyperglycemia effect
Glycated haemoglobin level in blood and reduce and reduce thermal hyperalgesia (Eddys Hot plate, Tail flick), motorcoordination,
as compared to the animals of control group. Effect of test drug Sapindus Mukroosi was assessed by
behavioural and biochemical parameters (Serum Glucose Level, Lipid peroxidation, reduced Gluthathione) in the brain
tissue of wistar rats. After 28 days treatment of Sapindus Mukroosi with low (250 mgkg) and higher (500 mgkg) dose
in diabetic rats showed antidiabetic action by reduction in hyperglycemia. Sapindus showed good result also in
behavioural and biochemical parameters such as Thermal hyperalgesia, motor coordination in comparison with
diabetic control group. The most promising effect of Sapindus seen with 500mgkg after treating period. It significantly
decrease serum glucose level, Glycated haemoglobin, lipid peroxidation and improving reduced gluthathione level as
compared to diabetic control rats. Thus Sapindus Mukroosi due to its antioxidant and antidiabetic property can be
concluded as a effective or preventive treatment for Diabetic Neuropathy. Streptozotocin induce hyperglycemia and
causes increase in oxidative stress and this conditions are oppose by treatment with Sapindus Mukroosi by inhibit the
generation of free radicals and improving self antioxidant GSH level significantly.
Key words: Diabetic Neuropathy, Glycated Haemoglobin, Neuropathic Pain.
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