Abstract

The process of drug discovery in pre-genomic era was considered as very complex process requiring great deal of time and money with high degree of unpredictability. The genomic research revolution has brought strategic shift in the concept of drug discovery and development with availability of tool for early identification of molecular targets based on human genomics. This approach has led to reduced rate of compound attrition and rejection, making process of drug discovery more viable economically and to some extent predictable with respect to time frame. The criteria of compound which make the compound fit for passing the process of drug discovery are studied and gene based targets are indentified, validated and interpreted. This approach no doubt is at its infantile stage but has tremendous future potential to play key role in drug discovery process. The present review describes the interrelationship between the druggability of genome and its impact on drug discovery process.

Key words: Druggability, Drug Discovery, Drug Targets, Genome