The main objective of this review is to unify and interpret widely scattered information of reported studies on potential, reliable and efficient analytical methodologies which can estimate all the major components of antihypertensive drugs. The information and suggested outlined below may facilitate and guide further needed studies to optimize the use of analytical techniques like High Performance Liquid Chromatography (HPLC), High Performance Thin Layer Chromatography (HPTLC), Gas Chromatography (GC) etc. for determination of antihypertensive analytes in formulation. Presented work is focused on the use of different analytical methods for the estimation of antihypertensive drugs in API as well as formulation. The first, Hypertension, Antihypertensive drugs their mechanism were described. From the reviewed literature it is obvious that HPLC is a commonly available method of testing in pharmaceutical laboratory so this method should be of choice for complete determination of all the components. Selection of analytical methods is determined by several factors such as speed, convenience, specificity, accuracy, precision, sensitivity, selectivity, cost, availability of instruments, technical expertise and the number of samples to be analyzed.
Key words: Anti hypertensive analytes, HPLC, HPTLC
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