Abstract

Objectives: To analyze the changing pattern that occurs in glucose two hours after eating from patients with type 2 diabetes. The changing pattern of glucose is shown based on the length of treatment that varies from 3 to 29 days.
Methodology: Data were obtained from medical records of Type 2 diabetes patients while undergoing treatment at the Hasanuddin University Hospital, Indonesia during 2015-2016. The total number of samples was 418 out of 50 patients. The glucose of type 2 diabetes patients is a longitudinal data which modeled through the penalized quadratic spline regression.
Results: There were four patterns of glucose based on length of treatment in which the pattern indicates that the glucose tends to decrease at the beginning of treatment until the second week of treatment. The glucose increases for the third to the fourth week, so that it needs attention from doctors and patients.
Conclusion: The pattern of glucose change two hours after meals based on treatment duration for a month of treatment tends to change in every week. This shows the need for analysis of the pattern of glucose change at each time interval of a particular treatment.

Key words: Glucose. Length of treatment. Longitudinal study. Type 2 diabetes. Quadratic penalized spline.