Background: Currently, intermittent pneumatic compression (IPC) is a standard method of lymphedema treatment. Recently, the effect of this modality in patients with limb arterial insufficiency has been researched. It has been suggested that the arterial inflow to the long bones is also increased by IPC. The purpose of this paper is to assess the effect of lower limb IPC on the blood flow as well as delayed bone uptake. Methods: In this prospective study, we evaluated 30 patients who were referred for whole body bone scan to our Nuclear Medicine Department. All the patients had been examined by a vascular surgeon for ruling out any peripheral neuropathy, vasculopathy or ulcer in the lower limbs. Also, all the patients were questioned about hypertension, diabetes mellitus, and other chronic diseases with peripheral complications. Following 925MBq of 99mTc-methylenediphosphonate (MDP) injection, perfusion and blood pool images of both legs as well as static delayed images were done after the completion of IPC. Results: Thirty patients (10 male) with the age range of 30–84 years (mean = 53.4) were included. Radiotracer uptake in flow and blood pool images in the compressed limb was significantly more than the contralateral limb, however, on delayed images, no significant difference was noted between two limbs. Conclusion: Although IPC can significantly increase blood flow of the compressed limb, MDP uptake on the delayed images was not increased. According to this study, IPC may not be useful as a technique to increase releasing chemotherapy drugs or other substances to the bone and promoting bone growth.
Intermittent pneumatic compression, IPC, bone scan, MDP uptake, vascular flow.
Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease.
Goulding SR, Anantha J, Collins LM, Sullivan AM, O'Keeffe GW
Neural regeneration research. 2022; 17(1): 38-44
Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury.
Tang W, Guo ZD, Chai WN, Du DL, Yang XM, Cao L, Chen H, Zhou C, Cheng CJ, Sun XC, Huang ZJ, Zhong JJ
Neural regeneration research. 2022; 17(3): 577-586
B-Cell Analysis for Monitoring Patients Undergoing B-Cell Depletion for the Treatment of Autoimmune Diseases.
Damoiseaux JGMC, van Beers JJBC, Busch M, van Paassen P
Methods in molecular biology (Clifton, N.J.). 2022; 2313(): 45-55
Intracellular flow cytometric lipid analysis - a multiparametric system to assess distinct lipid classes in live cells.
Boumelhem BB, Pilgrim C, Zwicker VE, Kolanowski JL, Yeo JH, Jolliffe KA, New EJ, Day ML, Assinder SJ, Fraser ST
Journal of cell science. 2022; 135(5):
Programmable dual responsive system reconstructing nerve interaction with small-diameter tissue-engineered vascular grafts and inhibiting intimal hyperplasia in diabetes.
Li Y, Wang Y, Xue F, Feng X, Ba Z, Chen J, Zhou Z, Wang Y, Guan G, Yang G, Xi Z, Tian H, Liu Y, Tan J, Li G, Chen X, Yang M, Chen W, Zhu C, Zeng W
Bioactive materials. 2022; 7(): 466-477