The present study was conducted to evaluate the effect of clanobutin sodium and menbutone diethanolamine each alone on some male fertility parameters of male goats. Moreover, the possible adverse effects of repeated administration of these drugs on the foeti of pregnant female rats and/ or induction of abortion were evaluated. Therefore, two experiments were carried out; the first was done on 15 apparently healthy mature un-castrated male goats of Zaraibi breed (1.5-2 year old) were divided into 3 equal groups. The 1st group: goats received basal ration and water without any treatment, the 2nd group: goats administered with clanobutin sodium (20 mg/kg b.wt in the 1st day and 10 mg/kg b.wt. in the 2nd day weekly for 8 weeks) and the 3rd group: goats administered with menbutone diethanolamine (10 mg/kg b.wt in the 1st day and 5 mg/kg b.wt. in the 2nd day weekly for 8 weeks). The second experiment was done on 45 pregnant female rats were divided into 3 equal groups. The 1st group of rats received basal ration and water, the 2nd group: rats administered with clanobutin sodium (40 mg/kg b.wt from 5th to 15th day of pregnancy period) and the 3rd group: rats administered with menbutone diethanolamine (20 mg/kg b.wt from 5th to 15th day of pregnancy period). The obtained results showed that administration of these drugs showed a deteriorating effect on male and female fertility parameters. Both drugs induced significant decrease in sperm concentration, sperm progressive motility, normal sperm %, in comparison with the control group of male goats all over the periods of the experiment. Also, the drugs induced a significant reduction in serum testosterone with significant increase on serum FSH and LH levels with harmful histophthological alterations in testis and epididymis Moreover, in the second experiment number, weights of foeti and number of live foeti on both uterine horns of pregnant female rats was significantly decreased with increased number of dead foeti on both clanobutin sodium and menbutone diethanolamine treated groups of rats in comparison with the control group.
These results concluded that the use of both drugs on male or female animals intended for breeding must be avoided.
Key words: clanobutin sodium, menbutone diethanolamine, semen characters , testis, epididymis, pregnant female.
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