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Influence of the potential dependent calcium channel blockers to the development of carrageenan-induced aseptic inflammation

Ziyovuddin Zaynutdinovich Khakimov, Alisher Khudayberdievich Rakhmanov, Nodira Bakhadirovna Bekova, Kodir Shukurlaevich Shukurlaev.


Background: A number of patients with diseases of the cardiovascular system simultaneously take anti-inflammatory medicines due to the presence of concomitant chronic inflammatory diseases such as rheumatism, arthritis, and podagra. Considering the above, it seems important to study the effect of calcium antagonists (CA) on the course of the inflammatory process.

Aim and Objectives: The purpose of the study was an investigation of the effect of amlodipine, diltiazem, and cinnarizine in comparison with diclofenac sodium on the course of carrageenan-induced aseptic arthritis.

Materials and Methods: The experiments were carried out on outbred white rats, males, and weigh 150–170 g. The inflammation was induced by the subplantary injection of a 1% aqueous solution of carrageenan in a volume of 0.1 ml. The studied medicines diclofenac sodium at a dose of 10 mg/kg, amlodipine and diltiazem at doses of 20 mg/kg, and cinnarizine at doses of 50 mg/kg were intragastrically administered to experimental animals 1 h before the injection of carrageenan. Measurement of the paw volume of animals was carried out using a plethysmometer

Results: The anti-inflammatory activity of amlodipine in the indicated hours of observation was 34.1, 36.8, 37.8, and 39.7%, respectively. Сinnarizine also had a distinct anti-exudative effect, after 1, 2, 3, and 4 h of the experiment value of anti-inflammatory activity of it were as following: 38.6, 40.3, 41.9, and 44.0%, respectively.

Conclusion: Blockers of potential-dependent calcium channels clearly suppress the exudative phase of aseptic inflammation. The studied medicines are arranged in a descending order by their pharmacological activity in the following row: diclofenac sodium = diltiazem> cinnarizine> amlodipine.

Key words: Inflammation; Carrageenan; Calcium antagonists

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