Fabrication of Buccal Dissolving Tetrahydro Curcumin Loaded Polyvidone Fiber Mat: Synthesis, Characterization, and In Vitro Evaluations
Ravikumar Rramaswamy, Ganesh Mani, Hyun Tae Jang.
Abstract
A simple high molecular weight polyvidone (PVP) with tetrahydro curcumin (THC) loaded nanofiber was prepared and in-vitro dissolution was evaluated. Various polymeric concentration solution of PVP was prepared, from which 10% w/v PVP solution was used to load 10% w/w THC. The morphology of the prepared nanofibers was evaluated using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier-transform-infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and ultraviolet-visible (UV-Vis) spectroscopy. The prepared mat released around 91% of the loaded THC within the first 5 minutes of the dissolution evaluation, which might be suitable for a buccal delivery system with a higher dissolution rate.
Key words: Polyvinylpyrrolidone; Nanofibers; Tetrahydro curcumin; Electrospinning; In vitro evaluations
The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
We use cookies and other tracking technologies to work properly, to analyze our website traffic, and to understand where our visitors are coming from. More InfoGot It!
