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Original Article



Synthesis, Biological Evaluation, and Docking Analysis of Methyl Hydroquinone and Bromo Methyl Hydroquinone as Potent Cyclooxygenase (COX-1 and COX-2) Inhibitors

Nursamsiar, Aiyi Asnawi, Rahmana E. Kartasasmita, Slamet Ibrahim, Daryono Hadi Tjahjono.




Abstract

In the present investigation, synthesis, biological evaluation, and molecular docking were performed for both methyl hydroquinone (1) and its brominated compound (2) to evaluate their anti-inflammatory activity against cyclooxygenase protein as a model compound and the data compared with its native ligands.

Key words: Bromination, Cyclooxygenase, Hydroquinone, Inflammation, NSAIDs






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