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Original Article



Synthesis, Biological Evaluation, and Docking Analysis of Methyl Hydroquinone and Bromo Methyl Hydroquinone as Potent Cyclooxygenase (COX-1 and COX-2) Inhibitors

Nursamsiar, Aiyi Asnawi, Rahmana E. Kartasasmita, Slamet Ibrahim, Daryono Hadi Tjahjono.



Abstract
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In the present investigation, synthesis, biological evaluation, and molecular docking were performed for both methyl hydroquinone (1) and its brominated compound (2) to evaluate their anti-inflammatory activity against cyclooxygenase protein as a model compound and the data compared with its native ligands.

Key words: Bromination, Cyclooxygenase, Hydroquinone, Inflammation, NSAIDs

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070809101112010203040506
20252026

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