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Study of response and outcome of treatment of radiotherapy in patients of carcinoma cervix Stage IIB–IV with concurrent cisplatin

Tamanna Vinaik.




Abstract
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Background: Carcinoma cervix is most common carcinoma among middle and low socioeconomic countries due to illiteracy and unhygienic conditions.

Objectives: The objectives of the study were to evaluate the response and outcome of radiotherapy along with cisplatin as chemotherapy in carcinoma cervix Stage II B–IV.

Materials and Methods: This is a prospective analytical study on 93 patients for 2 years in tertiary care hospital.

Results: In the present study disease-free survival rate at 1 year after treatment was 72.04%. Follow-up was in the range of 4–18 months. In the present study, overall survival rate at 1 year after treatment was 77.4%. In our study, of 93 patients, 21 patients succumbed to death at the end of 1 year. Among them, 10 patients (47.61%) died due to acute renal failure and rest died due to cardio-respiratory failure.

Conclusion: Conventional fractionation radiotherapy holds its utility in terms of efficacy and safety profile in the management of carcinoma cervix. The use of External Beam Radiation Therapy with chemotherapeutic drugs, i.e., cisplatin has showed high compliance to radiotherapy.

Key words: Carcinoma Cervix; Disease-Free Survival; Radiotherapy; Chemotherapy






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